Decreto Ketoconazole HRA
Decreto Ketoconazole HRA
Cari Soci, abbiamo appena ricevuto la notizia che il tanto atteso decreto Ketoconazole HRA è stato pubblicato ieri (in vigore da oggi 18 marzo 2016): confermiamo che il farmaco è in Classe A – PHT (distribuzione diretta), prescrivibile con ricetta non ripetibile da centri ospedalieri o specialisti (endocrinologo, internista) per il controllo dell’ipercortisolismo.
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Pratica Clinica
Cosa pretendere nel referto di una buona ecografia testicolare
Carlotta Pozza & Andrea. M. Isidori
Un referto ecografico deve contenere informazioni in grado di descrivere adeguatamente il quadro clinico valutato per l'intera durata dell'ecografia, e deve riportare eventuali difficoltà riscontrate nell’eseguire l’esame, per stimarne il valore diagnostico.
Nello stilare il referto di un’ecografia testicolare, generalmente si inizia descrivendo le tonache scrotali e di rivestimento dei testicoli, andando ad evidenziare eventuali alterazioni (per es. “ispessimento delle tonache per aumentato riflesso cremasterico; segni di pachivaginalite”).
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Aggiornamento Clinico ScientificoEffect of antihypertensive treatment at different blood pressure levels in patients with diabetes mellitus: systematic review and meta-analyses
a cura di Marco Giorgio Baroni
Mattias Brunström, Bo Carlberg
BMJ. 2016 Feb 24; 352: i717
To assess the effect of antihypertensive treatment on mortality and cardiovascular morbidity in people with diabetes mellitus, at different blood pressure levels.
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Aggiornamento Clinico Scientifico Metformin Attenuates 131I Induced Decrease in Peripheral Blood Cells in Patients With Differentiated Thyroid Cancer
A cura di Giuseppe Bellastella
Athanasios Bikas, Douglas Van Nostrand, Kirk Jensen, Sameer Desale, Mihriye Mete,Aneeta Patel, Leonard Wartofsky, Vasyl Vasko, and KennethD. Burman
Thyroid (2016)26 280 285
Background: 131I treatment (tx) of differentiated thyroid cancer (DTC) is associated withhematopoietic toxicity. It was hypothesized that metformin could have radioprotective effects on bone marrow function.The objective was to determine whether metformin prevents 131I-induced changes in complete blood counts (CBC) in patients with DTC.
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Aggiornamento Clinico Scientifico
Vitamin D 20,000 IU per week for five years does not prevent progression from prediabetes to diabetes
a cura di Massimo Procopio
Jorde R, Sollid ST, Svartberg J, Schirmer H, Joakimsen RM, Njølstad I, Fuskevåg OM, Figenschau Y, Hutchinson MYS
J Clin Endocrinol Metab. 2016 doi: 10.1210/jc.2015-4013
Vitamin D deficiency is associated with insulin resistance and risk of future diabetes.
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Aggiornamento Clinico Scientifico
Variations in clinical and imaging findings by time of diagnosis in women with hypopituitarism attributed to lymphocytic hypophysitis
a cura di Annamaria De Bellis
Tirosh A, Hirsch D, Robenshtok E, Masri-Iraqi H, Yoel U, Toledano Y, Twito O, Tsvetov G, Shimon I.
Endocr Pract. 2015 Nov 23.
To describe the various patterns of presentation, including assisting analyses, associated with the timing of diagnosis, among women with hypopituitarism and suspected clinical diagnosis of lymphocytic hypophysitis.
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Aggiornamento Clinico Scientifico Factors predicting pasireotide responsiveness in somatotroph pituitary adenomas resistant to first-generation somatostatin analogues: an immunohistochemical study
A cura di Laura Trementino
Iacovazzo D, Carlsen E, Lugli F, Chiloiro S, Piacentini S, Bianchi A, Giampietro A, Mormando M, Clear AJ, Doglietto F, Anile C, Maira G, Lauriola L, Rindi G, Roncaroli F, Pontecorvi A, Korbonits M, De Marinis L.
Eur J Endocrinol. 2016;174(2):241-50
AIM: To gather data regarding factors predicting responsiveness to pasireotide in acromegaly.
PATIENTS AND METHODS: SSTR2a, SSTR3, SSTR5, AIP, Ki - 67 and the adenoma subtype were evaluated in somatotroph adenomas from 39 patients treated post-operativelywith somatostatin analogues (SSAs). A standardized SSTR scoring system was applied (scores 0-3). All patients received first-generation SSAs, and 11 resistant patients were subsequently treated with pasireotide LAR.
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Aggiornamento Clinico Scientifico
Endogenous and exogenous testosterone and the risk of prostate cancer and increased prostate specific antigen (PSA): a meta- analysis
A cura di Francesco Romanelli & Andrea Sansone
Boyle P, Koechlin A, Bota M, d'Onofrio A, Zaridze DG, Perrin P, Fitzpatrick J, Burnett AL, Boniol M.
BJU Int. 2016 Jan 18. doi: 10.1111/bju.13417. [Epub ahead of print]
To review and quantify the association between endogenous and exogenous testosterone and prostate specific antigen (PSA) and prostate cancer. METHODS:Literature searches were performed following the PRISMA guidelines.
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Aggiornamento Clinico Scientifico Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents
A cura di Flavia Prodam
Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR
Teen-LABS Consortium - N Engl JMed.2016;374:113-123.
BACKGROUND: Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining the efficacy and safety of weight- loss surgery are available to support clinical decision making.
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Aggiornamento Clinico Scientifico Thiazide-associated hypercalcemia: incidence and association with primary hyperparathyroidism over two decades.
A cura di Massimo Procopio
Griebeler ML, Kearns AE, Ryu E, Thapa P, Hathcock MA, Melton LJ, Wermers RA.
J Clin Endocrinol Metab. 2016 doi: 10.1210/jc.2015- 39
Context:Thiazide diuretics,the antihypertensive agent prescribed most frequently worldwide,are commonly associated with hypercalcemia. However, the epidemiology and clinical features are poorly understood.
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